Annie's A Team For Quest for a Cure Walkathon

RETT SYNDROME RESEARCH TRUST, INC.

Annie's A Team For Quest for a Cure Walkathon


Annie's A Team For Quest for a Cure Walkathon

Thank you for visiting our fundraising page for Annie's A-Team and Quest for a Cure Walkathon being held on Sunday, Oct. 6, 2013 at Inglenook Park in Southfield, MI

Donating through this website is simple, fast and totally secure. It is also the most efficient way to support our fundraising efforts.

Annie's A-Team is walking once again to help cure Rett Syndrome.  As always your donation will go to the Rett Syndrome Research Trust (RSRT).  Informaion about RSRT can be found under the "Nonprofit" tab above, or by visiting their website at www.reverserett.org.  

This year we have decided to support a specific research project.  All donations will go to Ben Philpot, a researcher at the University of North Carolina at Chapel Hill, and his project to activate the silent MECP2 gene in Rett Syndrome. All girls with Rett Syndrome have 2 copies of MECP2 on each cell, a healthy copy and a Rett Syndrome copy. Dr. Philpot is screening drugs to “turn on” the healthy MECP2 gene, curing Rett Syndrome at the genetic level. $156,000 is needed by December 2013 to fund this project.

Rett Syndrome: Is a spontaneous, genetic neurological disorder that affects girls almost exclusively. Annie was born healthy, grew and developed normally until about 12 months old when she suddenly regressed, loosing all hand function, ability to ambulate and every word she spoke. Girls with Rett remain cognitively age appropriate, however become trapped in bodies that are no longer able to function properly, they require 24 hour care for the rest of their lives. Rett Syndrome is the symptoms of autism, cerebral palsy, Parkinson’s, epilepsy, and anxiety disorder all in 1 little girl.


Hope: Since it’s discovery in the early 1980’s the research in Rett has brought hope. In 1999 Dr. Zohgbi discovered the gene that causes Rett, MECP2. The fact that we have a gene, a single gene makes research into a cure easier. In 2007 Dr. Bird’s lab reversed Rett Syndrome in a mouse model. This proof of principle experiment shows that if/when MECP2 is restored symptoms of Rett Syndrome reverse essentially curing the disease.


Why Ben Philpot?  Ben Philpot’s lab will screen for compounds that can reactivate the silent (healthy) MECP2 gene already in a girl with Rett. MECP2 has proved to be a very complex, with this approach we don’t need to understand what MECP2 is responsible for we just need to turn it on. Ben has been successful in finding a drug to activate the silent copy of the gene responsible for Angelman’s Syndrome. Because he is familiar with this type of research and has been successful in the past we are very hopeful that his now streamlined approach will move faster, be more efficient and has promise of being successful in curing Annie, all girls currently suffering with Rett and the 16 girls that continue to get diagnosed every day. To watch a video about this research please Click HERE

Thank you for making a difference in the lives of these precious girls!

Information about Quest for a Cure walkaton can be found at www.questforacure.net

Many thanks for your support -- and don't forget to forward this to anyone who you think might want to donate too!

 

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Annie's A Team For Quest for a Cure Walkathon
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